Teshome Mitiku began performing at local schools and nightclubs when he was just a teenager. In the late 60's, singer and keyboardist Teshome Mitiku; his brother and alto saxophonist, Theodros "Teddy" Mitiku; trumpeter, Tamrat Ferendji; bassist Fekade Amde-Meskel; drummer, Tesfaye Mekonnen; guitarist, Alula Yohannes and singer, Seifu Yohannes; formed the influential Soul Ekos Band. The band released numerous songs. Teshome Mitiku composed and wrote Gara Ser New Betesh, Yezemed Yebada, Mot Adeladlogn and Hasabe.
Currently He lives in Washington DC